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“I was depressed, severely depressed for that whole time.”Five months earlier, in October 2022, Bentley had started taking Mounjaro for weight loss. Ozempic uses the active ingredient semaglutide, and Wegovy is the version approved for weight loss. Mounjaro uses tirzepatide, which also targets a second hormone called GIP, and Zepbound is its brand name for weight loss. Safety in pregnancyEven as GLP-1 medicines may increase fertility, little is known about their safety during pregnancy. “It’s kind of like heart failure or sleep apnea,” he said, referring to conditions for which GLP-1 drugs have recently shown positive results.
Persons: CNN — Catera Bentley, Bentley, , , ” Bentley, she’d, , , ’ Bentley, Jody Dushay, Dushay, Catera Bentley, Ivy, Daniel Drucker, ” Drucker, they’re, Drucker, Eli Lilly, ” Dushay, haven’t, That’s, Anuja Dokras, Dokras, Melanie Cree, Cree, PCOS, aren’t, Eli Lilly’s, Daniel Skovronsky, ” Skovronsky, Dr, Sanjay Gupta, it’s, Mounjaro Organizations: CNN, Beth Israel Deaconess Medical Center, Harvard Medical School, University of, Mount Sinai, Novo Nordisk, Zepbound, US Centers for Disease Control, University of Pennsylvania, PCOS, Children’s Hospital, National Institutes of Health, CNN Health Locations: Steele , Alabama, Mount, United States, Children’s Hospital Colorado, , Colorado
Sandra TorresTorres has a rare disorder called Laron syndrome that is caused by a genetic mutation. “This is how powerful this mutation seems to be.”What is Laron syndrome? Laron syndrome is a recessive gene, so only those who receive a copy from each parent will be affected. The condition leads to extreme obesity, a trigger for diabetes, heart disease, cancer and other diseases. While technically overweight at 100 pounds (45.4 kilograms), she was in good health, with no signs of diabetes or heart disease.
Persons: Paola Castro Torres, ” Torres, Torres, , ” Nathaly Paola Castro Torres, Sandra Torres Torres, , Valter Longo, Longo, Laron, Jaime Guevara, Aguirre, Guevara, ” Longo, ” Guevara, Andrew Freeman, Freeman, ” Hope, it’s Organizations: CNN, gerontology, University of Southern, of Endocrinology, Laron, Jewish Health Locations: Los Angeles, Quito, Ecuador, University of Southern California, Israel, Yemen, East, United States, Croatia, Ireland, Denver
Hedge fund managers gathered Wednesday at the 2024 Sohn Investment Conference in New York to share their best investment ideas. It kicked off with "Next Wave Sohn," a session that features ideas from rising stars within the hedge fund industry. Endocrinology is an $8 billion market, but the cumulative market size, including the company's future therapy targets, is upward of $200 billion, which includes estimates for future obesity drugs, the investor said. It has CA$75 billion market cap with an "unbelievable record of success," according to the investor. The short seller noted that the company has a $5 billion market cap with about $4.8 billion of debt.
Persons: Sohn, Eric Wolff, Wolff, Michelle Ross, Cushing, Ross, Eli Lilly, Crinetics, XBI, Nikhil Daftary, Alimentation, Daftary, Chris Drose, Nate Koppikar, Fahmi Quadir Organizations: Investment, Gumshoe Capital Management Investment, Pason Systems Energy, Pason Systems, Gumshoe Capital Management, StemPoint, Pharmaceuticals, Crinetics Pharmaceuticals, StemPoint Capital, Endocrinology, Novo Nordisk, P Biotech, NK Capital Investment, NK Capital, Starbucks, McDonalds, Bleecker Street Capital, Orso Partners, Justice Department, Federal Trade Commission, Safkhet, Global Education Locations: New York, Canada, U.S
CNN —An Alabama Supreme Court ruling that decided frozen embryos are children, and those who destroy them can be held liable for wrongful death, shows a new way in which the overturning of Roe v. Wade can affect how embryos are viewed under certain state laws. That decision is the first known case in which a US court has ruled that frozen embryos are human beings. Events leading up to the Alabama Supreme Court decision can be traced to 2006, when the criminal statute for homicide in the state was changed to include in utero. President Joe Biden said in a statement Thursday that the Alabama Supreme Court decision was a “direct result” of the overturning of Roe. “From the beginning, I’ve been warning that the fall of Roe v. Wade wasn’t just about abortion – and the recent Alabama Supreme Court ruling proves that,” Illinois Sen. Tammy Duckworth, who introduced the legislation with Pennsylvania Rep. Susan Wild, wrote in an email Thursday.
Persons: Roe, Wade, Mack, Carmack, ” Dr, Shaun Williams, , Williams, Joe Biden, ” Biden, , Dr, Sanjay Gupta, I’ve, Wade wasn’t, , Illinois Sen, Tammy Duckworth, Susan Wild, ” CNN’s Devan Cole Organizations: CNN, An, An Alabama Supreme, Alabama, of, Democratic, Senate, CNN Health, , Pennsylvania Locations: An Alabama, US, Alabama, Connecticut, of Alabama, , America, Illinois
The University of Alabama at Birmingham health system announced on Wednesday that it was pausing in vitro fertilization treatments as it evaluated the Alabama Supreme Court’s ruling that frozen embryos should be considered children. “We are saddened that this will impact our patients’ attempt to have a baby through I.V.F.,” a statement from the health system said, “but we must evaluate the potential that our patients and our physicians could be prosecuted criminally or face punitive damages for following the standard of care for I.V.F. treatments.”The health system’s Division of Reproductive Endocrinology and Infertility will continue performing egg retrievals from women seeking fertility treatment, the statement said, but it will not undertake the next steps in the process — combining the eggs with sperm in a lab for fertilization, and allowing embryos to develop — for now. “Everything through egg retrieval remains in place,” the statement said. “Egg fertilization and embryo development is paused.”
Persons: Organizations: University of Alabama, Reproductive Locations: Birmingham, Alabama, I.V.F
Minority Children in US Get Poorer Healthcare, Analysis Finds
  + stars: | 2024-01-17 | by ( Jan. | At P.M. | ) www.usnews.com   time to read: +2 min
By Nancy Lapid(Reuters) - The quality of healthcare for minority children in the United States is universally worse than it is for white children, even after accounting for insurance coverage, an analysis of dozens of recent studies found. The pattern was similar across all medical specialties, including newborn care, emergency medicine, primary care, surgery, hospital care, endocrinology, mental health care, care for developmental disabilities, and palliative care, researchers said. Even after adjusting for type of health insurance, family socioeconomic position, and other health conditions, the disparities were clear. “Across multiple healthcare specialties, non-white children receive poorer care relative to white children," study coauthor Dr. Monique Jindal of the University of Illinois Chicago School of Medicine said in an email. “The impacts of housing, employment, health insurance, the criminal justice system, and immigration are impossible to disentangle and are cumulatively responsible” for the poorer care for minority children, she said.
Persons: Nancy Lapid, Monique Jindal, , Jindal, Bill Berkrot Organizations: University of Illinois Chicago School of Medicine, Adolescent Locations: United States
Maker of Wegovy, Ozempic showers money on U.S. obesity doctors
  + stars: | 2023-12-01 | by ( ) www.reuters.com   time to read: +23 min
Novo spent at least $25.8 million over the past decade on U.S. medical professionals to promote its two obesity drugs, Wegovy and Saxenda, the analysis found. Jastreboff has also worked on clinical trials of obesity drugs for Eli Lilly, which markets a Wegovy competitor. Some doctors said Novo’s payments exemplify how the flood of industry money can dominate decision-making about care and coverage. Government pharmacy officer Solaru said her agency concluded that the new obesity drugs could be cost-effective by preventing other weight-related diseases and boosting workplace productivity. In January, the personnel office told its health plans they must cover at least one GLP-1 obesity drug for 8 million workers, retirees and family members.
Persons: Lee Kaplan, Kaplan, , gastroenterologist, He’s, Novo, Donna Ryan, Ryan, , ” Kaplan, ” Novo, Robert Lustig, “ I’m, Lustig, They’re, Ania, ” Jastreboff, Jastreboff, Eli Lilly, Lilly’s Zepbound, Lilly, ” Lilly, Novo’s, Ayana, Sanders, Arthur Kellermann, ” Kellermann, mouthpieces, ’ ”, “ I'm, Jamy Ard, Ard, Dele, ” Solaru, ” Ryan, Scott Kahan, Kahan, Solaru, Christine Gallagher, Wegovy, Rebekah Carl, Carl, Jen Wexler, gaunt, Wexler Organizations: Novo Nordisk, Dartmouth, Nutrition Institute, Massachusetts General Hospital, Harvard Medical School, Reuters, Cambridge, Obesity Society, U.S ., Management, Reuters . Pharmaceutical, , U.S, United, National Health Service, University of California, U.S . Food, Drug Administration, Doctors, Wegovy’s, BMI, Yale University’s Center, Weight Management, Wall Street, American Medical Association, Rutgers University’s School of Public Health, Affordable, . Pharmaceutical, Companies, Uniformed Services University of Health Sciences, Wake Forest University, Wake Forest Baptist Health Weight Management, Obesity, Pennington Biomedical Research, U.S . National Institutes of Health, Personnel Management, Coalition, STOP, George Washington University, Novo Locations: CAMBRIDGE, Massachusetts, Boston, U.S, Novo, Danish, United States, Louisiana, San Francisco, Wegovy, Pennington, Baton Rouge , Louisiana, Government, New Columbia , Pennsylvania, Florida
Walking pace could impact diabetes risk, study finds
  + stars: | 2023-11-28 | by ( Kristen Rogers | ) edition.cnn.com   time to read: +5 min
Brisk walking is associated with a nearly 40% lower risk of developing type 2 diabetes later in life, according to the study published Tuesday in the British Journal of Sports Medicine. But prior findings haven’t offered much guidance on the optimal habitual walking speed needed to lower diabetes risk, and comprehensive reviews of the evidence are lacking, the authors said. Going a certain pace during your walk may help lower your type 2 diabetes risk, according to a new study. Walking at a “fairly brisk” pace meant a 24% lower risk than those who easily or casually walked. Each kilometer increase in walking speed above brisk was associated with a 9% lower risk of developing the disease.
Persons: it’s, — it’s, , Ahmad Jayedi, haven’t, Robert Gabbay, Gabbay wasn’t, Carmen Cuthbertson, wasn’t, Gabbay, Dr, Michio Shimabukuro, Shimabukuro wasn’t, Borja del Pozo Cruz, ” del Pozo Cruz, ” Gabbay Organizations: CNN’s, CNN, British, of Sports Medicine, Health Research Center, Semnan University of Medical Sciences, American Diabetes Association, East Carolina University, Fukushima Medical University School of Medicine, University of Cadiz, US Centers for Disease Control Locations: Iran, United States, United Kingdom, Japan, Spain
Still life of Wegovy an injectable prescription weight loss medicine that has helped people with obesity. Novo Nordisk's Wegovy cut the risk of serious cardiovascular complications in people with obesity and heart disease in a closely watched trial, demonstrating a particularly large effect on heart attacks, a promising new frontier for the drug. The roughly 17,500-person Select study tested Wegovy in people with obesity and heart disease but who did not have diabetes. The new data could also help the Danish pharmaceutical company maintain its lead over Eli Lilly, whose competing weight-loss drug Zepbound was approved in the U.S. earlier this week. Zepbound has been shown to help people lose more weight, but it hasn't yet demonstrated an effect on cardiovascular outcomes.
Persons: Robert Kushner, Eli Lilly, Zepbound, Howard Weintraub Organizations: Wegovy, American Heart Association Scientific Sessions, New England, of Medicine, Novo Nordisk, Northwestern University Feinberg School of Medicine, Center for, NYU Langone Locations: Danish, U.S
You Won’t Lose Weight on Ozempic Forever
  + stars: | 2023-09-18 | by ( Dani Blum | More About Dani Blum | ) www.nytimes.com   time to read: +2 min
But doctors say some people seek out these drugs to lose as much weight as possible — and are dismayed and disillusioned when they stop. When they do, they tend to regain the weight they lost. Medications like Ozempic mimic a naturally occurring hormone and slow the emptying of the stomach, so that we feel fuller, faster and for longer. In clinical trials of semaglutide, the compound in Ozempic and Wegovy, people with diabetes have tended to lose less weight, less quickly, than people who did not have the condition, Dr. Hagan said. A small proportion of those who take these drugs won’t lose weight at all, he added.
Persons: ” Ms, Meinecke, Scott Hagan, Hagan, Andrew Kraftson Organizations: University of Washington, Michigan Medicine
Maria Vorontsova, Putin's daughter, is a scientist at Moscow State University. Vorontosova, Putin's eldest daughter, is a researcher at Moscow State University specialising in endocrinology, or the study of the system in the body that regulates hormones. The three articles published in MPDI publications appeared in 2022 and 2023, according to Vorontsova's university research profile. Her sister, Katerina Tikhoniva, is a dancer and also works in a senior position at Moscow State University, Reuters reported. In the wake of the Ukraine invasion, the US and other Western allies of Ukraine imposed sanctions on Putin's family.
Persons: Vladimir Putin's, Maria Vorontsova, Vladimir, Putin's, Young Vladimir Putin, Vorontsova, MDPI, Putin, Lyudmila Putina, Mikhail Fridman, Katerina Tikhoniva, Tikhonova's Organizations: Moscow State University ., Service, Moscow State University, US Endocrine Society, Moscow Times, Getty, Putin Reuters, Reuters, US Treasury Locations: Ukraine, Wall, Silicon, Russian, Russia, MDPI, Dresden, Germany, Dutch, Netherlands, Moscow
That’s the median weight loss experienced by people who take Wegovy, a drug from Novo Nordisk. Many patients started by taking Ozempic, a diabetes drug also by Novo Nordisk that led to weight loss as a side effect. Mounjaro, made by Eli Lilly and approved for treating diabetes, is expected to be approved soon for obesity. While price and insurance coverage pose problems for patients, health economists expect prices to come down as more drugs are approved and companies face competition. Medicare is forbidden by law to pay for weight-loss drugs, although there is an intense lobbying effort to change that.
Persons: Eli Lilly, David A, Eli Lilly’s, , , Ania, Robert F, Kushner Organizations: Novo Nordisk, Duke University, Yale University, Northwestern University Feinberg School of Medicine, Locations: Novo
That’s particularly a concern for older adults, obesity medicine experts say. The more muscle someone over the age of 65 loses, the greater their risk of becoming frail or suffering a fracture or fall (which can be fatal in older adults). It is crucial for older adults to maintain muscle mass so that they can stay mobile and independent. Muscle mass naturally dwindles with age. Clinical trials on semaglutide, the active ingredient in Ozempic and Wegovy, have typically enrolled people in their 40s and 50s.
Persons: — you’re, Scott Hagan, Janice Jin Hwang Organizations: University of Washington, University of North Carolina School of Medicine
[1/3] A selection of injector pens for the Wegovy weight loss drug are shown in this photo illustration in Chicago, Illinois, U.S., March 31, 2023. It highlights the challenge Novo and rivals face in convincing European governments to pay for obesity drugs, which analysts say is likely to slow their take-up there. Germany's health ministry told Reuters there were no plans to change the law to cover weight loss drugs. DIFFERENT PICTUREIn the United States, the federal Medicare health plan for older Americans is prohibited from covering weight-loss drugs. Many health plans paid for by large employers will cover Wegovy, although they may require that patients try a rigorous diet programme or cheaper drugs first.
Persons: Jim Vondruska, Wegovy, Martin Merkel, Merkel, Duane Mellor, Novo, Lars Fruergaard Jorgensen, Michael Wirtz, Terence McManus, Phil McEwan, they've, McEwan, Patricia Weiss, Josephine Mason, Catherine Evans Organizations: REUTERS, Novo Nordisk, Wegovy, Europe's, pharma, European Union, Endocrinology Society, Aston University in, Reuters, Bellevue Asset Management, Barclays, Thomson Locations: Chicago , Illinois, U.S, Germany, FRANKFURT, Aston University in Birmingham, England, Wegovy, Europe, Danish, Berlin, Norway, Denmark, Britain, United States, Switzerland, Bellevue, EU, Cardiff , Wales, Frankfurt
However, experts who treat and study menopause say the study is unable to draw a direct connection to later-life dementia and that the overall benefits of hormone replacement therapy, or HRT, far outweigh the risks for many patients. “One finding in the study was a link between dementia and the use of HRT for a very short time span, under a year. Researchers compared people with dementia who had used hormone therapy, even briefly, with those from the larger group who had not. The chance of being diagnosed with dementia went up with years spent on HRT, the study found. When women used 12 or more years of hormone therapy, the association with a diagnosis of dementia rose to 74%, Pourhadi said.
Persons: , Nelsan, Pauline Maki, David Curtis, Kejal, Kantarci, Andrea Lenzi, University of Rome La Sapienza, ” Pourhadi, Pourhadi, Maki, ” Maki, Susan Davis, Amanda Heslegrave, ” Heslegrave Organizations: CNN, Danish Dementia Research, Copenhagen University Hospital Rigshospitalet, University of Illinois, UCL Genetics Institute, University College London, Mayo Clinic, University of Rome La, University of Illinois’s Center for Research, Women’s, Monash University, Dementia Research Locations: Danish, Denmark, Chicago, neuroradiology, Rochester , Minnesota, Taiwan, Melbourne, Australia, London
Novo Nordisk 's high-dose experimental obesity pill helped overweight or obese adults lose around 15% of their body weight, according to new late-stage clinical trial results. Novo Nordisk told Reuters it plans to file for Food and Drug Administration approval of the drug later this year. But the highest dose of Rybelsus is 14 milligrams, while the company's experimental obesity pill has a far larger dose of 50 milligrams. Other companies are also developing oral weight loss treatments to appeal to those who don't want weekly injections. Pfizer is also developing its own weight loss pill, called danuglipron, which patients take twice a day.
Persons: Eli Lilly, Dr, Filip Knop, Knop, Eli Lilly's, Elon Musk Organizations: Novo Nordisk, Reuters, Food and Drug, Pfizer, University of Copenhagen, Novo, Companies, Novo Nordisk's Ozempic, National Institutes of Health Locations: Danish
Videos related to the subject “food noise explained” have been viewed 1.8 billion times on TikTok. When food noise fadesWendy Gantt, 56, said she first heard the term food noise on TikTok, where she had also learned about Mounjaro. Ozempic is more of a way to silence the food noise than anything else, she said. “It’s not like a magic drug that’s giving people an easy way out.”What causes food noise? There is no clinical definition for food noise, but the experts and patients interviewed for this article generally agreed it was shorthand for constant rumination about food.
Persons: Wendy Gantt, , , Kelsey Ryan, hasn’t, It’s, Ryan, “ It’s, Robert Gabbay, Janice Jin Hwang Organizations: American Diabetes Association, University of North Carolina School of Medicine Locations: Ozempic, Canandaigua, N.Y
“This study captures why obesity is a disease — there are actual changes to the brain,” said Apovian, who was not involved in the study. They wanted to know if that would be different in people with obesity compared to those of normal weight. At the same time, levels of dopamine rose in those at normal weight, signaling that the reward centers of the brain were also activated. Losing weight did not reset the brain in people with obesity, Serlie said. Until science answers these questions, the study emphasizes, once again, that weight stigma has no place in the fight against obesity, Serlie said.
Persons: ’ ”, Caroline Apovian, , Apovian, Sadaf, they’ve, , Mireille Serlie, ” Faroof, ” Serlie, Farooqi, Serlie, it’s, ” Farooqi, Organizations: CNN, Harvard Medical School, Center, Weight Management, Wellness, Brigham, Women’s Hospital, BMI, University of Cambridge, Yale School of Medicine Locations: Boston, New Haven , Connecticut
The majority of those bills specifically affect transgender people, touching on nearly every aspect of a transgender person's public life. And the vulnerability of most Republican state legislators right now is in the primary, if at all," Allen said. The bill he signed on Wednesday also adds obstacles for transgender adults and grants courts jurisdiction in child custody battles in some cases involving gender-affirming care. Demonstrators swarmed the Texas House, leading lawmakers to send a bill banning gender-affirming care back to committee. In Montana, protests contributed to the censure of transgender state Representative Zooey Zephyr, who was banned from the state House floor by Republican legislators.
[1/2] The American Medical Association logo is seen at their office in Washington, D.C., U.S., August 30, 2020. REUTERS/Andrew Kelly/March 30 (Reuters) - As powerful new obesity drugs enter the U.S. market, medical associations are keen to advise their members on how to best use them for patients. "These new compounds are game changers, there's no doubt about it," said Anthony Comuzzie, chief executive of The Obesity Society. The group last provided obesity treatment guidelines in 2013 alongside the American Heart Association and American College of Cardiology. OBESITY AS A DISEASEThe American Medical Association, the nation’s largest medical group, recognized obesity as a disease in 2013.
The aggressive legislative push comes as battles over gender and sexuality increasingly are being fought in U.S. classrooms, courtrooms and political campaigns. Republicans including former President Donald Trump have embraced restricting trans rights ahead of the 2024 White House race, a push that trans advocates fear will harm transgender children. Gender-affirming care covers a variety of treatments, including puberty blockers, hormone therapy and, in exceedingly rare cases for trans people under 18, surgery. But many opponents of trans rights believe that the sex assigned at birth is immutable and distrust the prevailing opinions of medical associations with specialties in pediatrics, endocrinology and mental health. Governors in South Dakota and Utah have already signed into law gender-affirming care bans that state legislatures passed this year.
Intensive behavioral and lifestyle changes should be the first-line approach, but the AAP also includes recommendations for anti-obesity medications and surgery for the first time. The guidelines say that pediatricians should offer weight-loss drugs for children age 12 and up with obesity. She also acknowledged that these lifestyle changes can be really hard to adopt, especially for overworked and low-income parents. The more adverse the environment around you, the harder it is to live a healthy lifestyle,” Hassink said. Medications and surgery are expensive, and asking overstretched parents to implement lifestyle changes is not always realistic.
And Black women are often in their late 30s or early 40s when they start, older on average than white women. Black women are also twice as likely as white women to have fertility challenges, according to a 2008 study in Fertility and Sterility. He suggested that insurance coverage, awareness of the “biological clock” and partners’ attitudes toward fertility treatment may all play a role. Regina Townsend via Broken Brown Egg‘The myth assigned to us’National data identifying racial disparities in fertility care only recently became available when Seifer published his 2007 study. Doctors’ lack of knowledge about racial disparities in fertility treatment doesn’t surprise Townsend.
The startup's platform matches surrogate mothers with prospective parents they want to work with. Unlike traditional agencies, Nodal allows surrogate mothers to pick families they want to work with. Nodal is a surrogacy-matching platform that uses tech to connect surrogate mothers with prospective parents. Prospective parents pay $500 per month to join the platform for the first six months. Nodal is launching with 30 surrogates and six times as many prospective parents and hopes to grow its team in time.
0В авторитетном журнале Lancet Diabetes & Endocrinology опубликованы результаты крупномасштабного исследования связи между индексом массы тела и новой коронавирусной инфекцией. Авторы, изучившие медицинские записи почти 7 миллионов англичан, пришли к выводу, что не только избыточный, но и недостаточный вес увеличивает риск тяжёлого течения COVID-19, пишет ria.ru. Результаты показали, что риск тяжёлой формы и смерти от COVID-19 начинает расти у людей с ИМТ выше 23. Второй интересный момент — учёные также наблюдали ухудшение исходов заболевания у людей с пониженным ИМТ — менее 18,5. Поэтому, чтобы подстраховаться от осложнений при COVID-19, авторы исследования призывают избавиться от избыточного веса, но не доводить себя до истощения.
Organizations: Endocrinology Locations: COVID, Великобритания
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